Is NMN…
…the magic pill that can slow our aging down?
Have you heard of NMN (or under its full name nicotinamide mononucleotide)? Over the recent years longevity research started to study its effects on aging animals. The results look positive. Unfortunately the clinical trials on humans are lacking at the moment. The main reason is the cost. That is not stopping an ever growing amount of people to take NMN on a daily basis. They believe that they can benefit from some of its potential anti-aging capabilities. The production of NMN is quite costly. The hefty price tag is something you might need to take into account if you consider taking NMN on a daily basis.
What is NMN actually?
NMN is a type of a molecule called a bioactive nucleotide. Nucleotides help building our DNA. Our bodies produce it naturally. But you can also boost in a form of a supplement. In the body NMN is converted to NAD+ (nicotinamide adenine dinucleotide). NAD+ is an essential coenzyme found in every cell.
Why do we need it?
NAD+ is necessary for various biological processes. Such can be the metabolic process, DNA repair or gene expression. It also helps us deal with inflammation.
NMN and aging
As we age our levels of NMN and consecutively of NAD+ decline. This decline has a negative impact on proteins that repair our DNA. The Decline of NMN decreases mitochondrial function. Also it increases oxidative stress in our cells. Additionally decrease of NMN also means that our arteries are struggling to repair themselves. This causes a higher risk of cardiovascular disease. Unfortunately our cells cannot absorb NAD+ if taken orally or via IV, only NMN can be absorbed this way.
We can find a good amount of studies of NMN and its impact on longevity in animals. The most the trials we can come across use mice. One thing to note is that these use significantly higher dosages of NMN compared to their body weight to what we generally consider safe for humans. Nevertheless the results look promising. Unfortunately the clinical trials with humans have been minimal and using very small samples of population.
Natural sources of NMN
We all can support increase of NAD+ in our body. But the amounts we would be able to realistically consume through our diet are not large enough to have a significant impact on longevity. But the best foods for it are avocado, broccoli, edamame, cabbage or tomatoes. Another natural way we can boost our NAD+ is physical activity.
Is NMN the answer to longevity in humans?
NMN might not be the magic pill we all desire… Nevertheless it will be interesting to see what future the human trial results tell us regarding its impact. We also need more research on what is the best daily dosage. Despite a variety of unknown factors I have made a personal decision to start using NMN. I currently take 250 mg daily. I am not experiencing any side effects at the moment.
If you find NMN as fascinating as we do and would like to know more, click here (1) to read the scientific research focusing on NMN and aging.
Let’s stay in touch!
Have you tried using NMN? At what dose? Are there any other potential anti-aging chemicals you are adding to your regular diet? Let us know on our Instagram, TikTok or LinkedIn. Would you like to know more about DNA? Head to our article about biological age testing. Or check join me for a workout!
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Resources:
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice, Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, Alessia Grozio, Shunsuke Kubota, Yo Sasaki, Philip Redpath, Marie E. Migaud, Rajendra S. Apte, Koji Uchida, Jun Yoshino, Shin-ichiro Imai, Cell Metab. Author manuscript; available in PMC 2017 Dec 13., Cell Metab. 2016 Dec 13; 24(6): 795–806., Published online 2016 Oct 27. doi: 10.1016/j.cmet.2016.09.013, PMCID: PMC5668137, NIHMSID: NIHMS914373, PMID: 28068222, downoaded from the web 29/08/2024 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668137/
